Geftinat Tablets (Iressa or Gefitinib) is a cancer chemotherapy medication. GeftiNat (Iressa or Gefitinib) interferes with the growth of cancer cells and slows their growth and spread in the body. Gefitinib is used in the treatment of non-small cell lung cancer. Iressa tablets contain 250 mg of gefitinib and are available as brown film-coated tablets for daily oral administration
What are the Side Effects ?
GI disturbances, anorexia; hepatotoxicity; rash, acne, dry skin, skin blemishes; weakness; peripheral edema; amblyopia; a cough, dyspnoea; conjunctivitis; mouth ulceration; eye irritation, corneal membrane sloughing, ocular ischemia haemorrhage; pancreatitis; toxic epidermal necrolysis; erythema multiforme; hypersensitivity reactions. Potentially Fatal: Interstitial lung disease.GeftiNat (Iressa or Gefitinib) is indicated as monotherapy for the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of both platinum-based and docetaxel chemotherapies who are benefiting or have benefited from Gefitinib. GeftiNat (Iressa or Gefitinib) may also be used for purposes other than those listed in this drug information guide.
Serious side effects have been reported with the use of Iressa including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); lung problems; liver problems; eye problems; severe nausea, vomiting, loss of appetite, or diarrhea; and others.
Before taking gefitinib, tell your doctor if you are taking any other medicines, especially warfarin (Coumadin); rifampin (Rifadin, Rimactane); phenytoin (Dilantin, Phenytek); ketoconazole (Nizoral); itraconazole (Sporanox); or a stomach acid reducer such as cimetidine (Tagamet, Tagamet HB), ranitidine (Zantac, Zantac 75),esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), and others.
What Precautions should be taken ?
Severe renal or hepatic impairment; idiopathic pulmonary fibrosis; acute onset or worsening of pulmonary or eye symptoms. Monitor hepatic function periodically. Monitor regularly for changes in prothrombin time or International Normalized Ratio in patients on warfarin treatment.